Myofibroblast differentiation depends on sustained glycolysis, and therefore on lactate export. We are defining monocarboxylate transport as a target in pulmonary fibrosis.
Matrix production is a biosynthetic problem. We are identifying the nutrients fibroblasts consume to build extracellular matrix, and testing whether blocking their transport attenuates fibrosis.
Pulmonary artery smooth muscle cells proliferate in low oxygen when most cells stop. We are defining the metabolic signal that permits it, and testing whether blocking it prevents vascular remodeling.