The Oldham Lab in the Pulmonary and Critical Care Medicine Division and the Department of Medicine at Brigham and Women’s Hospital and Harvard Medical School investigates how cellular metabolic reprogramming contributes to the lung diseases pulmonary hypertension and pulmonary fibrosis. We study in vitro and in vivo model systems with state-of-the-art analytical techniques, including metabolomics, stable isotope tracing, extracellular flux analyses, systems biology, and network medicine. By improving our understanding of cell metabolism, we aim to develop new therapeutic strategies for the treatment lung diseases.