TGF-β coordinates alanine synthesis and import for myofibroblast differentiation in pulmonary fibrosis
JCI Insight. 11:e199449
Papers
PubMed · Google Scholar · ORCID
2026
Exploring the lung–liver axis in pulmonary arterial hypertension
Comprehensive Physiology. 16:e70171
Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis
Science Translational Medicine. 18:eads2673
Research Highlight: Crunkhorn S. Inhibiting lactate transport reduces lung fibrosis. Nature Reviews Drug Discovery. 2026.
ExplainBind: Explainable physicochemical determinants of protein–ligand binding via non-covalent interactions
bioRxiv
2025
Targeting NEDD9-SH3 with a covalent peptide controls endothelial phenotype
bioRxiv
Dyspnea and right-sided heart failure in a patient with a history of pneumonectomy
CHEST Pulmonary. 3:100149
Targeting type-2 inflammation in pulmonary hypertension: Lessons from a novel model
American Journal of Physiology-Lung Cellular and Molecular Physiology. 328:L669-L670
ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1
Cell. 188:2569-2585.e20
Exercise intolerance
In: Longo DL, Fauci AS, Kasper DL, et al., editors. Harrison's Principles of Internal Medicine. 22nd ed. McGraw Hill; 2025. p. 291-292.
Targeting cardiac fibrosis with a vaccine against fibroblast activation protein
Circulation Research. 136:41-43
Disturbances of respiratory function
In: Longo DL, Fauci AS, Kasper DL, et al., editors. Harrison's Principles of Internal Medicine. 22nd ed. McGraw Hill; 2025. p. 2201-2206.
Pharmacology of vascular tone
In: Golan DE, Loscalzo J, Namchuk M, editors. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. 5th ed. Philadelphia: Lippincott, Williams, & Wilkins; 2025. p. 489-506.
Mechano-dependent sorbitol accumulation supports biomolecular condensate
Cell. 188:447-464.e20
Antifibrotic therapies
In: Golan DE, Loscalzo J, Namchuk M, editors. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. 5th ed. Philadelphia: Lippincott, Williams, & Wilkins; 2025. p. 1094-1099.
2024
Leukemia inhibitory factor (LIF) receptor amplifies pathogenic activation of fibroblasts in lung fibrosis
Proceedings of the National Academy of Sciences. 121:e2401899121
Diverse NKT cells regulate early inflammation and neurological outcomes after cardiac arrest and resuscitation
Science Translational Medicine. 16:eadq5796
Branched-chain α-ketoacids aerobically activate HIF1α signalling in vascular cells
Nature Metabolism. 6:2138-2156
Exercise intolerance and low cardiac filling pressures in a woman with a novel eNOS mutation
Circulation: Genomic and Precision Medicine. 17
The bacterial quorum sensing signal 2’-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection
eLife. 13:RP97568
Exploring the molecular signatures of pulmonary vascular lesions
American Journal of Respiratory and Critical Care Medicine. 210:256-257
Immune mechanisms in fibrotic interstitial lung disease
Cell. 187:3506-3530
Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness
Cell Metabolism. 36:1335-1350.e8
Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension
American Journal of Physiology-Lung Cellular and Molecular Physiology. 326:L252-L265
APSselect award winner, American Physiological Society
Pulmonary hypertension
In: Singh AK, Loscalzo J, editors. Brigham Intensive Review of Internal Medicine. 4th ed. Philadelphia: Elsevier; 2024. p. 1028-1038.
New agents in pulmonary disease
In: Singh AK, Loscalzo J, editors. Brigham Intensive Review of Internal Medicine. 4th ed. Philadelphia: Elsevier; 2024. p. 470-476.
2023
Striated preferentially expressed gene deficiency leads to mitochondrial dysfunction in developing cardiomyocytes
Basic Research in Cardiology. 119:151-168
Elevated pulmonary arterial compliance is associated with survival in pulmonary hypertension: Results from a novel network medicine analysis
American Journal of Respiratory and Critical Care Medicine. 208:312-321
MYC overrides HIF-1α to regulate proliferating primary cell metabolism in hypoxia
eLife. 12:e82597
Single-cell transcriptomics reveal a hyperacute cytokine and immune checkpoint axis after cardiac arrest in patients with poor neurological outcome
Med. 4:432-456.e6
Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension
JCI Insight. 8:e163932
Metabolic regulation of species-specific developmental rates
Nature. 613:550-557
2022
L-2-hydroxyglutarate protects against cardiac injury via metabolic remodeling
Circulation Research. 131:562-579
2021
Interferon-γ impairs human coronary artery endothelial glucose metabolism by tryptophan catabolism and activates fatty acid oxidation
Circulation. 144:1612-1628
Understanding critically ill sepsis patients with normal serum lactate levels: Results from U.S. and European ICU cohorts
Scientific Reports. 11:20076
Integrating haemodynamics identifies an extreme pulmonary hypertension phenotype
European Respiratory Journal. 58:2004625
Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis
Cell Metabolism. 33:1342-1357.e10
Immunometabolic endothelial phenotypes: Integrating inflammation and glucose metabolism
Circulation Research. 129:9-29
NHLBI-CMREF workshop report on pulmonary vascular disease classification
Journal of the American College of Cardiology. 77:2040-2052
Systemic vascular distensibility relates to exercise capacity in connective tissue disease
Rheumatology. 60:1429-1434
Individualized interactomes for network-based precision medicine in hypertrophic cardiomyopathy with implications for other clinical pathophenotypes
Nature Communications. 12:873
2020
Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer
Nature Cancer. 2:66-82
Precision medicine in pulmonary hypertension
In: Gomez JL, Himes BE, Kaminski N, editors. Precision in Pulmonary, Critical Care, and Sleep Medicine. New York: Springer; 2020. p. 241-255.
2019
Reaction rate of pyruvate and hydrogen peroxide: Assessing antioxidant capacity of pyruvate under biological conditions
Scientific Reports. 9:19568
Pulmonary vascular distensibility and early pulmonary vascular remodeling in pulmonary hypertension
Chest. 156:724-732
Paradoxical embolization via large pulmonary arteriovenous malformation
American Journal of Respiratory and Critical Care Medicine. 200:29-30
Tumor-stroma mechanics coordinate amino acid availability to sustain tumor growth and malignancy
Cell Metabolism. 29:124-140.e10
Innate T cells in the intensive care unit
Molecular Immunology. 105:213-223
2018
[18F]Fluorocholine and [18F]fluoroacetate PET as imaging biomarkers to assess phosphatidylcholine and mitochondrial metabolism in preclinical models of TSC and LAM
Clinical Cancer Research. 24:5925-5938
Systems biology approaches to redox metabolism in stress and disease states
Antioxidants & Redox Signaling. 29:953-972
MicroRNA dysregulation in pulmonary arteries from chronic obstructive pulmonary disease. Relationships with vascular remodeling
American Journal of Respiratory Cell and Molecular Biology. 59:490-499
GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis
Nature. 561:263-267
NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension
Science Translational Medicine. 10:eaap7294
Network analysis to risk stratify patients with exercise intolerance
Circulation Research. 122:864-876
Editor's Pick, Circulation Research
Editorial: Arena R, Ozemek C, Laddu-Patel D, Myers J. Refining the risk prediction of cardiorespiratory fitness with network analysis. Circulation Research. 2018;122:804.
The long noncoding RNA LnRPT puts the brakes on pulmonary artery smooth muscle cell proliferation
American Journal of Respiratory Cell and Molecular Biology. 58:138-139
Polymorphonuclear leukocytes in pulmonary hypertension and fibrosis: Not always what they appear to be
American Journal of Respiratory Cell and Molecular Biology. 58:135-137
Pyridine dinucleotides from molecules to man
Antioxidants & Redox Signaling. 28:180-212
Nicotine adenine dinucleotides: The redox currency of the cell
Antioxidants & Redox Signaling. 28:165-166
Pulmonary hypertension
In: Singh AK, Loscalzo J, editors. Brigham Intensive Review of Internal Medicine. 3rd ed. Philadelphia: Elsevier; 2018. p. 906-916.
2017
2016
Postural tachycardia syndrome is not caused by deconditioning
Pulmonary Circulation. 6:401-401
Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension
Journal of Clinical Investigation. 126:3313-3335
Unexplained exertional dyspnea caused by low ventricular filling pressures: Results from clinical invasive cardiopulmonary exercise testing
Pulmonary Circulation. 6:55-62
Elevated pulmonary arterial and systemic plasma aldosterone levels associate with impaired cardiac reserve capacity during exercise in left ventricular systolic heart failure patients: A pilot study
The Journal of Heart and Lung Transplantation. 35:342-351
Quantification of 2-hydroxyglutarate enantiomers by liquid chromatography-mass spectrometry
BIO-PROTOCOL. 6
Pharmacology of vascular tone
In: Golan DE, Tashjian AH, Armstrong EJ, editors. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. 4th ed. Philadelphia: Lippincott, Williams, & Wilkins; 2016. p. 385-402.
2015
Protocol for exercise hemodynamic assessment: Performing an invasive cardiopulmonary exercise test in clinical practice
Pulmonary Circulation. 5:610-618
Hypoxia-mediated increases in L-2-hydroxyglutarate coordinate the metabolic response to reductive stress
Cell Metabolism. 22:291-303
Preview: Harris AL. A new hydroxyl metabolite of 2-oxoglutarate regulates metabolism in hypoxia. Cell Metabolism. 2015;22:198.
Research Highlight: Miura G. Cancer metabolism: two sides of a coin. Nature Chemical Biology. 2015;11:632.
2014
Network-based association of hypoxia-responsive genes with cardiovascular diseases
New Journal of Physics. 16:105014
Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis
Circulation. 130:168-179
2010
Cardiopulmonary exercise testing in the evaluation of unexplained dyspnea
Advances in Pulmonary Hypertension. 9:101-106
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